Clinical Features and Radiographic Aspects of Squamous Cell Carcinoma in the Gnathic Bones

Autores

  • Ludimila Lemes Moura Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru - SP, Brazil https://orcid.org/0000-0001-6811-3747
  • Guilherme Simpione Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru - SP, Brazil https://orcid.org/0000-0001-9039-1305
  • Mariela Peralta-Mamani Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru - SP, Brazil https://orcid.org/0000-0002-0243-9194
  • Paulo Sérgio da Silva Santos Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru - SP, Brazil https://orcid.org/0000-0002-0674-3759
  • Cassia Maria Fischer Rubira Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru - SP, Brazil https://orcid.org/0000-0003-2119-1144
  • Izabel Regina Fischer Rubira-Bullen Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru - SP, Brazil https://orcid.org/0000-0002-5069-9433

DOI:

https://doi.org/10.21270/archi.v12i4.6110

Palavras-chave:

Squamous Cell Carcinoma, Head and Neck Neoplasms, Diagnostic Imaging, Panoramic Radiography, Cone-Beam Computed Tomography

Resumo

This integrative review aimed to discuss the clinical features and imaging aspects of squamous cell carcinoma in the gnathic bones on panoramic radiographs and cone-beam computed tomography. The electronic search was conducted in PubMed, Embase, and Scopus using the keywords cone-beam computed tomography, panoramic radiography, dentomaxillofacial complex, and oral squamous cell carcinoma. Studies between 2012 and 2022, report imaging aspects of the oral squamous cell carcinoma in panoramic radiography and cone-beam computed tomography were selected. The initial search found 375 articles, leaving 171 after excluding duplicates. Eighteen studies met the inclusion criteria, bringing together a total of twenty cases. Swelling and pain are common clinical features. In most cases, the squamous cell carcinoma was in the mandible; the borders were poorly defined with invasive aspects; the internal structure was radiolucent/hypodense and some cases, had radiopaque flecks. The lesion causes structures destroyed like the adjacent bone, the alveolar process, border of the mandibular canal, ramus of the mandible. The image aspects raised in this review: as large areas of osteolysis interspersed with an irregular pattern of radiopaque/hyperdense flakes, with imprecise limits and invasive borders, causing significant destruction of adjacent structures, squamous cell carcinoma can be a diagnostic hypothesis. In these cases, we recommend urgency in completing the diagnosis. The panoramic radiography can provide information that leads to the suspicion of a malignant lesion, but cone-beam computed tomography provides the real dimension and repercussion of the lesion.

Downloads

Não há dados estatísticos.

Referências

Pérez MG, Bagán JV, Jiménez Y, et al. Utility of imaging techniques in the diagnosis of oral cancer. J Craniomaxillofac Surg 2015;43(9):1880-94.

Bhandari S, Rattan V, Panda N, et al. Oral cancer or peri-implantitis: A clinical dilemma. J Prosthet Dent 2016;115(6):658-61.

Abdelkarim AZ, Elzayat AM, Syed AZ, et al. Delayed diagnosis of a primary intraosseous squamous cell carcinoma: A case report. Imaging Sci Dent 2019;49(1):71-7.

Langton S, Cousin GCS, Plüddemann A, et al. Comparison of primary care doctors and dentists in the referral of oral cancer: a systematic review. Br J Oral Maxillofac Surg. 2020;58(8):898-917.

Rutkowska M, Hnitecka S, Nahajowski M, et al. Oral cancer: The first symptoms and reasons for delaying correct diagnosis and appropriate treatment. Adv Clin Exp Med 2020;29(6):735-43.

Nomura T, Monobe H, Tamaruya N, et al. Primary intraosseous squamous cell carcinoma of the jaw: two new cases and review of the literature. Eur Arch Otorhinolaryngol. 2013;270(1):375-9.

Bereket C, Bekçioğlu B, Koyuncu M, et al. Intraosseous carcinoma arising from an odontogenic cyst: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol 2013;116(6):445-9.

Adachi M, Inagaki T, Ehara Y, et al. Primary intraosseous carcinoma arising from an odontogenic cyst: A case report. Oncol Lett. 2014;8(3):1265-8.

Lukandu OM, Micha CS. Primary intraosseous squamous cell carcinoma arising from keratocystic odontogenic tumor. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;120(5):e204-9.

Beattie A, Stassen LF, Ekanayake K. Oral Squamous Cell Carcinoma Presenting in a Patient Receiving Adalimumab for Rheumatoid Arthritis. J Oral Maxillofac Surg 2015; 73(11):2136-41.

Geetha P, Avinash TML, Babu BB, et al. Primary intraosseous carcinoma of the mandible: A clinicoradiographic view. J Cancer Res Ther 2015;11(3):651.

Sukegawa S, Matsuzaki H, Katase N, et al. Primary intraosseous squamous cell carcinoma of the maxilla possibly arising from an infected residual cyst: A case report. Oncol Lett 2015;9(1):131-5.

Magalhaes MA, Somers GR, Sikorski P, et al. Unusual presentation of squamous cell carcinoma of the maxilla in an 8-year-old child. Oral Surg Oral Med Oral Pathol Oral Radiol 2016; 122:179-85.

Martínez-Martínez M, Mosqueda-Taylor A, Delgado-Azañero W, et al. Primary intraosseous squamous cell carcinoma arising in an odontogenic keratocyst previously treated with marsupialization: case report and immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol 2016;121(4):87-95.

Ai CJ, Jabar NA, Lan TH, et al. Mandibular Canal Enlargement: Clinical and Radiological Characteristics. J Clin Imaging Sci 2013;7:1-7.

Medawela RMSHB, Jayasuriya NSS, Ratnayake DRDL, et al. Squamous cell carcinoma arising from a keratocystic odontogenic tumor: a case report. J Med Case Rep. 2017;11(1):335.

Nokovitch L, Bodard AG, Corradini N, et al. Pediatric case of squamous cell carcinoma arising from a keratocystic odontogenic tumor. Int J Pediatr Otorhinolaryngol 2018;112:121-5.

Bajpai M, Chandolia B, Pardhe N, et al. Primary Intra-Osseous Basaloid Squamous Cell Carcinoma of Mandible: Report of Rare Case with Proposed Diagnostic Criteria. J Coll Physicians Surg Pak. 2019;29(12):1215-7.

Wu RY, Shao Z, Wu TF. Chronic progression of recurrent orthokeratinized odontogenic cyst into squamous cell carcinoma: A case report. World J Clin Cases 2019;7(13):1686-95.

Luo XJ, Cheng ML, Huang CM, et al. Reduced delay in diagnosis of odontogenic keratocysts with malignant transformation: A case report. World J Clin Cases. 20206;8(11):2374-9.

Lee WB, Hwang DS, Kim UK. Sequential treatment from mandibulectomy to reconstruction on mandibular oral cancer - Case review I: mandibular ramus and angle lesion of primary intraosseous squamous cell carcinoma. J Korean Assoc Oral Maxillofac Surg. 2021 Apr 30;47(2):120-7.

Prosdócimo ML, Agostini M, Romañach MJ, et al. A retrospective analysis of oral and maxillofacial pathology in a pediatric population from Rio de Janeiro-Brazil over a 75-year period. Med Oral Patol Oral Cir Bucal 2018;23(5):511-7.

Borrás-Ferreres J, Sánchez-Torres A, Gay-Escoda C. Malignant changes developing from odontogenic cysts: A systematic review. J Clin Exp Dent. 2016 Dec 1;8(5):e622-8.

Kumchai H, Champion AF, Gates JC. Carcinomatous Transformation of Odontogenic Keratocyst and Primary Intraosseous Carcinoma: A Systematic Review and Report of a Case. J Oral Maxillofac Surg. 2021 May;79(5):e1081-9.

Bombeccari GP, Candotto V, Giannì AB, et al. Accuracy of the Cone Beam Computed Tomography in the Detection of Bone Invasion in Patients with Oral Cancer: A Systematic Review. Eurasian J Med 2019;51(3):298-306.

Pałasz P, Adamski Ł, Górska-Chrząstek M, et al. Contemporary Diagnostic Imaging of Oral Squamous Cell Carcinoma - A Review of Literature. Pol J Radiol 2017;82:193-202.

Publicado

2023-04-06

Como Citar

Moura, L. L., Simpione, G., Peralta-Mamani, M., Santos, P. S. da S., Rubira, C. M. F., & Rubira-Bullen, I. R. F. (2023). Clinical Features and Radiographic Aspects of Squamous Cell Carcinoma in the Gnathic Bones. ARCHIVES OF HEALTH INVESTIGATION, 12(4), 584–591. https://doi.org/10.21270/archi.v12i4.6110

Edição

Seção

Original Articles